SAN DIEGO, April 27 (Bernama) -- Crown Bioscience, a wholly-owned subsidiary of Crown Bioscience International has enhance its existing portfolio of humanised drug target models by launching a new transgenic CD3E model to advance development of immuno-oncology (I/O) drugs.
CrownBio addresses this need with their new CD3E transgenic model that was validated in collaboration with and developed by NBRI of Nanjing University, a statement said. NBRI is a leading company in China providing high-quality human disease related animal models for biomedical community as well as pharmaceutical companies. Novel therapeutic T-cell redirecting antibodies, including bispecific T cell engagers, show great promise in effectively treating cancer. However, development of these drugs is hampered by a lack of in vivo models that can accurately recapitulate human specific responses. The CD3E model expresses the human form of CD3E and is phenotypically normal with levels of T, B, and NK cells comparable to control. These features make it an ideal model for determining the efficacy of CD3 targeted T cell redirecting therapies through direct assessment of T cell activation, antigen recognition and related intracellular signal transduction pathways. "Data generated from our new CD3E models demonstrate their unique ability to guide development of bispecific T cell engagers and other T cell redirecting therapies," said Dr Davy Ouyang, Director of Translational Oncology at CrownBio. "We are very excited about the potential these innovative models have to uncover new insights in the discovery and development of cutting-edge I/O agents." Crown Bioscience is a global drug discovery and development services company providing translational platforms to advance oncology, inflammation, cardiovascular and metabolic disease research. Learn more about CrownBio's new CD3E model by visiting https://www.crownbio.com/immuno-oncology/hugemm/cd3e-mouse-model -- BERNAMA
0 Comments
- Achieves large current drive and high-accuracy control while cutting power consumption
TOKYO, April 26 (Bernama-BUSINESS WIRE) -- Toshiba Electronic Devices & Storage Corporation (“Toshiba”) today announced “TB67S128FTG,” a bipolar stepping motor driver with a 50V/5A rating and support for 128 micro steps. Sample shipments start from the end of this month. This press release features multimedia. View the full release here:https://www.businesswire.com/news/home/20180426005612/en/ High speed and high performance motor control and lower power consumption are required for applications that include 3D printers, office equipment, banking terminals such as ATMs, cash dispensers, amusement machines, and home appliances. To meet these conflicting requirements, Toshiba has applied its original current optimization technology, AGC[1], to a new motor driver IC that achieves a large current drive (50V/5A rating). Recent years have seen increasing demand for equipment offering higher accuracy and quieter operation. Toshiba’s new motor driver IC realizes high accuracy and low vibration by delivering 128 micro steps, realizing a much higher definition than conventional 32-step devices. It also uses SMD[2], a current adjustment function, to reduce noise and vibration effectively during motor drive by selecting the SMD configuration best suited for each motor. Use of another Toshiba original current detection technology, ACDS[3], reduces the number of components required for driver control, contributing to lower system costs and improved flexibility in board pattern design. http://mrem.bernama.com/viewsm.php?idm=31778 KUALA LUMPUR, April 26 (Bernama) -- Madison Realty Capital (MRC) will provide a US$35 million (RM 134.4 million) mezzanine loan to co-developers Sumaida + Khurana and LENY for a condominium tower in Manhattan, New York, US. The funding is part of a US$155 million (RM 595.2 million) construction financing package for the project provided by MRC and an investment fund managed by Apollo Global Management. The project located in the evolving Hudson West neighborhood will stand 35 stories in height, encompass 163,329 square feet and feature 83 residences, ranging from one-bedrooms to expansive penthouses, a statement said. The building development team Sumaida + Khurana is a New York-based development firm focused on developing seminal buildings throughout the city while LENY has been responsible for the development of millions of square feet of residential projects around the world. The building is being designed by Pritzker Prize-winning architect Álvaro Siza. IA award-winning architects, Michael Gabellini and Kimberly Sheppard will collaborate with Siza on the building's interiors and SLCE Architects will serve as the Architect of Record. The condominium will also feature a significant amount of outdoor space, including a landscaped roof garden and sun deck, as well as numerous private terraces for the residents including access to art fitness center, children's playroom and space to host private events. "We continue to be successful in meeting the needs of borrowers at all stages of the development process, from predevelopment to construction to sellout or stabilization," said co-founder and managing principal MRC,Josh Zegen. Sales are slated to begin in Spring 2019 and Leonard Steinberg, Debra LaChance, and Justin D'Adamo at Compass will lead the marketing efforts. MRC is a New York-based real estate investment firm that pursues real estate equity and debt investments in the middle market. --BERNAMA KUALA LUMPUR, April 26 (Bernama) -- Westinghouse Electric Company has received fuel load permit from China´s National Nuclear Safety Administration (NNSA) for world´s first unit of AP1000 nuclear power plant located in Sanmen, Zhejiang Province, China.
Westinghouse won the bid for China´s generation III+ nuclear power projects to build two units of AP1000 reactors in Sanmen, Zhejiang Province and two units in Haiyang, Shandong Province in 2007. Westinghouse´s president, Asia Region, Gavin Liu said Westinghouse is proud to be a partner in China´s forward-looking nuclear energy program, an effort that will provide clean-air electricity to power China´s economy. The China State Nuclear Power Technology Corporation (SNPTC) and CNNC Sanmen Nuclear Power Company Limited (SMNPC) are also the companies receiving the permit. Initial fuel loading has commenced, a statement said. The plant, Sanmen Unit 1 has successfully completed all the necessary functional tests as well as technical, safety and Chinese regulatory reviews. The fuel load process will be followed by initial criticality, initial synchronisation to the electrical grid, and conservative, step by step, power ascension testing, until all testing is safely and successfully completed at 100 per cent power. "Through technology transfer, localization and infrastructure development, Westinghouse continues to collaborate with our Chinese partners and supports the development of China´s nuclear power industry, " Liu added. "This is the next major step in delivering the world´s first AP1000 plant to our customer and demonstrating the benefits of our advanced passive safety technology to the world, " said Westinghouse president and chief executive officer, Jose Emeterio Guti?ez. --BERNAMA KUALA LUMPUR, April 26 (Bernama) -- Jam City -- a Los Angeles based mobile games studio, announced that the new mobile game Harry Potter: Hogwarts Mystery is now available to be downloaded on the App Store and Google Play.
"There are so few moments where a mobile entertainment company has the chance to truly bring magic into the world and we have been thrilled by the amazing response our game has already received from Harry Potter fans everywhere, " said co-founder and chief executive officer of Jam City, Chris DeWolfe. He added that Jam City have been working hard to ensure that any aspiring witch or wizard can enter Hogwarts through their smartphones and tablets and begin their magical journeys. Developed by Jam City in partnership with Warner Bros. Interactive Entertainment, it is the first mobile game where players create their own character and experience life as a Hogwarts student, a statement said. The game launched under Warner Bros. Interactive Entertainment's Portkey Games, a label dedicated to creating new mobile and video game experiences that place the player at the center of their own adventure, inspired by J.K. Rowling´s original stories. In the game, players will progress as a student through Hogwarts, joining one of its four houses. Players will be able to create and upgrade personalised characters using an avatar customisation system, learn an arsenal of magical skills and form relationships with other students. Players will also be able to master everything from crafting potions under Snape´s critical eye, to Transfiguration with Professor McGonagall. Along with interactive spellcasting, the game features an encounter system where narrative choices impact parts of the story, the statement added. For more details, visit www.HarryPotterHogwartsMystery.com/. -- BERNAMA |
Archives
April 2023
|